Bovine serum albumin-Camptothecin nanoparticles for RNAs packaging to improve the prognosis of Cancer
| 期刊 | International journal of biological macromolecules |
| 发表日期 | 2024-Dec |
| 作者 | Song Yun; Liu Hui; Zhao Nannan; Chen Jiao; Zhang Xiaoming; Zhang Hongyang; Wu Tao; Ruan Haihua; Qu Guoxin |
| DOI | 10.1016/j.ijbiomac.2024.136997 |
| PMID | 39476892 |
原始摘要
xRNAs have received a lot of attention for their potential in targeted therapy. This study aims to construct nanoparticles using bovine serum albumin (BSA) and Camptothecin to improve the bioavailability and targeting of drugs through RNA packaging, thereby improving the prognosis of cancer patients. The phacoemulsification method was used to synthesize BSA-CPT-NPs, and the single factor orthogonal design method was used to optimize the process. The cytotoxicity of nanoparticles to cancer cells and their effect on intracellular RNA expression were evaluated in vitro. The results showed that the formation of BSA-Camptothecin nanoparticles was uniform, and the drug loading and RNA encapsulation efficiency reached a high level. Cell experiments showed that the nanoparticle significantly inhibited the proliferation of cancer cells and enhanced the anti-tumor effect by regulating the expression of xRNAs. The study confirmed the potential of BSA-Camptothecin nanoparticles packaged by RNA to improve the efficiency and targeting of drug delivery, and future research will focus on further exploring its feasibility in clinical applications for cancer therapy.
| 撤稿日期 | 2026-07-24 |
| 撤稿期刊 | International journal of biological macromolecules |
| 发布机构 | Netherlands |
| 通知PMID | 42493265 |
Retraction notice to "bovine serum albumin-camptothecin nanoparticles for RNAs packaging to improve the prognosis of cancer" [Int. J. Biol. Macromol. 282 (2024) 136997]