Tendon injury repair involves a variety of cellular and molecular pathways. The aim of this study was to explore the molecular mechanisms and interactions of recombinant proteins PTTG1IP, ADAM12, PAPSS1 and MYO1B in wound repair induced by tendon exposure. The study collected a dataset of gene expression related to tendon exposure from the GEO database. Differential gene expression analysis and Venn diagram analysis were used to identify the differentially expressed genes before and after tendon exposure injury, and potential diagnostic markers were screened. Appropriate statistical methods were used to analyze all data. The results show that the expression levels of PTTG1IP, ADAM12, PAPSS1 and MYO1B change dynamically after tendon exposure injury, and PTTG1IP, ADAM12, PAPSS1 and MYO1B play an important role in the wound repair process caused by tendon exposure. The change of its expression level and function is closely related to the wound healing process.