文献信息 RETRACTED

Protein polysaccharide molecules combine with exercise to promote bone and joint injury repair: protein kinase signaling pathway

期刊 International journal of biological macromolecules
发表日期 2025-May
作者 Hou Xingchen; Huan Meng; Zhang Youming; Zhang Jianhui; Lei Zhang; Zhang Xiangyu; Xu Yin; Mao Shukai
DOI 10.1016/j.ijbiomac.2025.142960
PMID 40210062
原始摘要

Bone and joint injuries are common motor system diseases that seriously affect the quality of life of patients. This study aims to explore the promoting effect of protein polysaccharide molecules combined with exercise on bone and joint injury repair, as well as the underlying protein kinase signaling pathway mechanism. Research on constructing protein polysaccharide complexes through molecular docking technology to analyze their construction characteristics and the properties of protein kinases. By constructing relevant signaling pathways and applying support vector machine technology, the potential signaling pathways of kinases were encoded and calculated for predictive analysis. Subsequently, the repair effect of bone and joint injuries was quantitatively evaluated by combining exercise methods. The research results indicate that the constructed protein polysaccharide complex can effectively activate related protein kinase signaling pathways, enhance the repair effect of bone and joint injuries. Through the combination of exercise methods, the healing time of bone injuries is significantly shortened, and the recovery of joint function is significantly improved. Therefore, the binding movement of protein polysaccharide molecules has a significant effect on promoting the repair of bone and joint injuries, and its mechanism of action is mainly achieved by activating the signaling pathways of specific protein kinases.

撤稿信息
撤稿日期 2026-07-22
撤稿期刊 International journal of biological macromolecules
发布机构 Netherlands
通知PMID 42481318
撤稿通知标题:
Retraction notice to "Protein polysaccharide molecules combine with exercise to promote bone and joint injury repair: protein kinase signaling pathway" [Int. J. Biol. Macromol. 309 (2025) 142960]
AI 提取信息
研究领域
基础医学
文章类型
原创研究(Original Research)
研究方法
生物信息学分析
疾病/条件
骨关节损伤
数据来源
实验室自产(Lab-generated)
撤稿原因
无法确定
撤稿类型
撤稿(Full Retraction)
研究机构
School of Physical Education and Health Sciences, Mudanjiang Normal University, Mudanjiang, Heilongjiang 157011, China; Physical Education and Research Department, Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China; School of Physical Education, Shanxi University of Finance and Economics, Taiyuan, Shanxi 030006, China; College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, Heilongjiang 157011, China; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China; Tennis Teaching and Research Section, Beijing Sport University, Beijing 100084, China; School of Physical Education, Southwest Medical University, Luzhou, Sichuan 646699, China
国家/地区
中国
资助来源
未提及
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